MySQL Enterprise Monitor Row Accesses:

Well, of course the first thing you do is check all your cacti monitors, because there is obviously something wrong with the monitoring system.
Cacti Innodb Row Accesses:

Hmm... it's not the monitor. Must be a change in the app...
So you check with everyone, and no, nothings changed in the app. In fact, nothing even appears to be different (same basic app response times, same # requests/sec to the app, etc, etc)
Database Activity:

So it must be a query cache issue...
Query Cache:

Apparently not... :(
So what could cause that kind of dramatic increase in index rows read / sec ?
In reality, looking at the data distribution, the optimizer apparently decided to 'explain' it all away....
Current explain plan:
mysql> \e
-> ;
+--------------+-------------------------------+---------+------+------+----------+
possible_keys
| key | key_len | ref | rows | filtered
| Extra
+--------------+-------------------------------+---------+------+------+----------+
UIDX_TOTAL_RATING_OWNER_ABOUT,IDX_TOTAL_RATING_ABOUT,IDX_TOTAL_RATING_OWNER
| UIDX_TOTAL_RATING_OWNER_ABOUT | 180 | NULL | 5 | 80.00
| Using where; Using index; Using filesort |
+--------------+-------------------------------+---------+------+------+----------+
1 row in set, 1 warning (0.00 sec)
Previous explain plan:
mysql> \e
-> ;
+--------------+-------------------------------+---------+------+------+----------+
possible_keys
| key | key_len | ref | rows | filtered
| Extra
+--------------+-------------------------------+---------+------+------+----------+
UIDX_TOTAL_RATING_OWNER_ABOUT,IDX_TOTAL_RATING_ABOUT,IDX_TOTAL_RATING_OWNER
|IDX_TOTAL_RATING_OWNER | 42 | const,const | 1 | 100.00
| Using where |
+--------------+-------------------------------+---------+------+------+----------+
1 row in set, 1 warning (0.03 sec)
Interesting what a little change in data and a different path through the optimizer can do...